Three ways to order the same 89 compounds: by the evidence behind them, by the risk documented against them, and by what people are actually trying to achieve. Every position is calculated from the monographs, the arithmetic is published on each page, and no ranking on this site is a recommendation.
All 89 compounds ordered by how much human evidence stands behind them. The top is almost entirely approved medicines; the bottom is where most of the compounds people ask about live.
The same library ordered by documented harm, absence of oversight and how much is simply unknown. A low position does not mean safe — it often means unstudied.
See the risk rankingThe question people actually type, answered from the evidence rather than by whoever is selling the answer. 9 goals, each ranked by weight of human evidence.
Subtract one score from the other and you get the number that matters most before anyone tries something: how far the documented downside outruns anything demonstrated about the upside.
The full gap table sits on the risk ranking.